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Important Safety Information (ISI)
SUBOXONE® (buprenorphine HCl/naloxone HCl dihydrate sublingual tablets) (CIII) is indicated for the treatment of opioid dependence.
It is extremely dangerous to take benzodiazepines or other depressants while taking SUBOXONE. A serious overdose and death may occur if benzodiazepines, sedatives, tranquilizers, antidepressants, or alcohol are taken at the same time as SUBOXONE.
SUBOXONE has potential for abuse and produces dependence of the opioid type, with a milder withdrawal syndrome than full agonists.
Cytolytic hepatitis and hepatitis with jaundice have been observed in the addicted population receiving buprenorphine.
Allergic reactions including bronchospasm, angioneurotic edema, and anaphylactic shock have been reported in patients taking buprenorphine.
There are no adequate and well-controlled studies of SUBOXONE (a Category C medication) in pregnancy.
Caution should be exercised when driving cars or operating machinery.
Always store buprenorphine-containing medications safely and out of the reach and sight of children. Destroy any unused medication appropriately.
The most commonly reported adverse events with SUBOXONE include: headache (36%, placebo 22%), withdrawal syndrome (25%, placebo 37%), pain (22%, placebo 19%), insomnia (14%, placebo 16%), nausea (15%, placebo 11%), and constipation (12%, placebo 3%). Please see full Prescribing Information for a complete list.
To report an adverse event caused by taking SUBOXONE, please call 1-877-782-6966. You are also encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full US Prescribing Information for SUBOXONE.
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Opioid dependence is more than a physical condition. The way you feel and the way you act are also part of your dependence—and that means counseling isn't just a "nice-to-have," but an essential part of your treatment.
In fact, medication and counseling together can help you stay in treatment and improve the likelihood of success. Counseling can also provide the support and guidance you need as you work to rebuild your relationships and get your life back on track.
On your first visit, you might begin the conversation by talking about your current situation, and how you've been feeling lately.
Explain that you're concerned about your use of opioids and think you may have become dependent. Or, if you're already in treatment, talk about your decision to get treatment, your hopes for the future, and what obstacles to success you may need help with. Counseling can also help you deal with the day-to-day challenges of getting opioid dependence under control.
Your counselor can help you:
You might want to discuss:
Create a list of questions to ask your counselor, and bring it along so you don't forget anything. You might also be wondering:
Print this guide and write in your own questions. You can also mark the questions you think are most important. Bring the guide along when you talk with your counselor—and get them answered.
Feel free to speak frankly and honestly. Remember, what you tell your counselor is private and will not be shared without your explicit permission.
Treatment for opioid dependence has 3 components: physical, psychological, and behavioral. Successful treatment includes addressing all 3 components. That's why making a commitment to counseling and finding the right counselor are so important.
Print this guide and take it along to your counselor appointment
Still looking for the right counselor? Let us help: call 866-973-HERE (4373) for help finding private, online, or group counseling.
You can also talk with your doctor about counseling. Or get tips on connecting with counseling, and learn more about how counseling and medication work together.

Let us help you make your first appointment: call 866-973-HERE (4373) for help finding private, online, or group counseling.
You can also talk with your doctor about counseling. Or get tips on connecting with counseling, and learn more about how counseling and medication work together.